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Study of the impact of different salts on the intrinsic dissolution rate of pharmaceutical compounds

Box, Karl, Ruiz, Rebeca, Outhwaite, Breeze and Lee, Sam (2017) Study of the impact of different salts on the intrinsic dissolution rate of pharmaceutical compounds. British Journal of Pharmacy, 2 (2). ISSN 2058-8356

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Abstract

The intrinsic dissolution rate (IDR) of a free base and its four salts were investigated with the aim of selecting the salt with the best dissolution performance. IDRs were measured using the Sirius inForm platform with quantitation by in-situ UV spectroscopy. Results showed that the hydrochloride salt had the highest dissolution rate followed by the maleate and p- toluenesulphonate salts, whilst the naphthalene-2-sulphonate and free base had the lowest IDR values. The Sirius inForm provides valuable insights into the dissolution behaviour of different drug forms during salt selection.

Item Type: Article
Uncontrolled Keywords: intrinsic dissolution rate, salt selection, spectroscopy, Sirius InForm
Subjects: R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
Schools: School of Applied Sciences
Depositing User: Megan Taylor
Date Deposited: 04 Dec 2017 14:28
Last Modified: 04 Dec 2017 14:28
URI: http://eprints.hud.ac.uk/id/eprint/34050

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