Search:
Computing and Library Services - delivering an inspiring information environment

Ex vivo studies for the passive transdermal permeation and extent of metabolism of methyl and butyl paraben from a cream

Hatami, Aida, Carr, Kevin, Whiteley, Paul, Wilkinson, Simon and Dodou, Kalliopi (2017) Ex vivo studies for the passive transdermal permeation and extent of metabolism of methyl and butyl paraben from a cream. British Journal of Pharmacy, 2 (2). ISSN 2058-8356

[img]
Preview
PDF - Published Version
Available under License Creative Commons Attribution.

Download (639kB) | Preview

Abstract

Concerns regarding the safety of cumulative exposure to parabens have been raised as a consequence of their estrogenic and endocrine effects. These antibacterial agents are commonly used in food, pharmaceutical and cosmetic products. Preliminary data from animal models has indicated potential links between paraben exposure and various conditions ranging from skin disorders to autism. Oral consumption of parabens is not a cause for concern because they are readily metabolised by the liver and excreted rapidly by the kidney. The presence of parabens in adipose tissue is thought to be due to dermal absorption of parabens where they are incompletely metabolised. Various studies have been performed on paraben absorption; however transdermal permeation of parabens from an emulsion has not been studied to date. In this preliminary study dermal permeation and metabolism across human skin were evaluated for methyl paraben (MP) and butyl paraben (BP) from an emulsion, using Franz Diffusion cell system with analysis by q-ToF (quadrupole time of flight) mass spectrometry. MP was observed to have lower permeation and lower extent of metabolism than BP.

Item Type: Article
Uncontrolled Keywords: paraben, skin metabolism, 4-hydroxybenzoic acid, mass spectrometry
Subjects: R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
Schools: School of Applied Sciences
Depositing User: Megan Taylor
Date Deposited: 06 Dec 2017 10:40
Last Modified: 06 Dec 2017 10:40
URI: http://eprints.hud.ac.uk/id/eprint/34049

Downloads

Downloads per month over past year

Repository Staff Only: item control page

View Item View Item

University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©