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Evaluating the Swelling, Erosion and Compaction Properties of Cellulose Ethers

Ghori, Muhammad U., Grover, Liam M., Asare-Addo, Kofi, Smith, Alan M. and Conway, Barbara R (2017) Evaluating the Swelling, Erosion and Compaction Properties of Cellulose Ethers. Pharmaceutical Development and Technology. ISSN 1083-7450

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Abstract

Swelling, erosion, deformation and consolidation properties can affect the performance of cellulose ethers, the most commonly used matrix former in hydrophilic sustained tablet formulations. The present study was designed to comparatively evaluate the swelling, erosion, compression, compaction and relaxation properties of the cellulose ethers in a comprehensive study using standardised conditions. The interrelationship between various compressional models and the inherent deformation and consolidation properties of the polymers on the derived swelling and erosion parameters are consolidated. The impact of swelling (Kw) on erosion rates (KE) and the inter-relationship between Heckel and Kawakita plasticity constants was also investigated. It is evident from the findings that the increases in both substitution and polymer chain length led to higher Kw, but a lower KE; this was also true for all particle size fractions regardless of polymer grade. Smaller particle size and high substitution levels tend to increase the relative density of the matrix but reduce porosity, yield pressure (Py), Kawakita plasticity parameter (b-1) and elastic relaxation. Both KW vs KE (R2 = 0.949-0.980) and Py vs b-1 correlations (R2 = 0.820-0.934) were reasonably linear with regards to increasing hydroxypropyl substitution and molecular size. Hence, it can be concluded that the combined knowledge of swelling and erosion kinetics in tandem with the in and out-of-die compression findings can be used to select a specific polymer grade and further to develop and optimise formulations for oral controlled drug delivery applications.

Item Type: Article
Contributors:
ContributionNameEmailORCID
AuthorGhori, Muhammad U.m.ghori@hud.ac.ukUNSPECIFIED
AuthorGrover, Liam M.UNSPECIFIEDUNSPECIFIED
AuthorAsare-Addo, Kofik.asare-addo@hud.ac.ukUNSPECIFIED
AuthorSmith, Alan M.a.m.smith@hud.ac.ukUNSPECIFIED
AuthorConway, Barbara Rb.r.conway@hud.ac.ukUNSPECIFIED
Uncontrolled Keywords: Methylcellulose; Hypromellose; Hydrophilic matrices; Matrix swelling; Martix erosion
Subjects: Q Science > QC Physics
R Medicine > RS Pharmacy and materia medica
Schools: School of Applied Sciences
Related URLs:
Depositing User: Muhammad Ghori
Date Deposited: 04 Oct 2017 12:29
Last Modified: 10 Oct 2017 14:00
URI: http://eprints.hud.ac.uk/id/eprint/33603

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