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The influence of hydroalcoholic media on the performance of Grewia polysaccharide in sustained release tablets

Nep, E.I., Mahdi, M.H., Adebisi, A.O., Dawson, C., Walton, K., Bills, P., Conway, B.R., Smith, A.M. and Asare-Addo, K. (2017) The influence of hydroalcoholic media on the performance of Grewia polysaccharide in sustained release tablets. International Journal of Pharmaceutics, 532 (1). pp. 352-364. ISSN 03785173

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Co-administration of drugs with alcohol can affect the plasma concentration of drugs in patients. It is also known that the excipients used in the formulation of drugs may not always be resistant to alcohol. This study evaluates effect of varying alcohol concentrations on theophylline release from two grades of Grewia mollis polysaccharides. X-ray microtomography showed that native polysaccharide formulation compacts were not homogenous after the mixing process resulting in its failure in swelling studies. Removal of starch from the native polysaccharide resulted in homogenous formulation compacts resistant to damage in high alcoholic media in pH 6.8 (40%v/v absolute ethanol). Destarched polymer compacts had a significantly higher hardness (375 N) than that of the native polysaccharide (82 N) and HPMC K4 M (146 N). Dissolution studies showed similarity at all levels of alcohol tested (f2 = 57-91) in simulated gastric media (pH 1.2). The dissolution profiles in the simulated intestinal fluids were also similar (f2 = 60-94), with the exception of the native polysaccharide in pH 6.8 (40%v/v absolute ethanol) (f2 = 43). This work highlights the properties of Grewia polysaccharide as a matrix former that can resist high alcoholic effects therefore; it may be suitable as an alternative to some of the commercially available matrix formers with wider applications for drug delivery as a cheaper alternative in the developing world.

Item Type: Article
Uncontrolled Keywords: HPMC K4M; Polysaccharide; Matrix tablets; Hydroalcoholic; Theophylline
Subjects: Q Science > Q Science (General)
Schools: School of Applied Sciences
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Depositing User: Kofi Asare-Addo
Date Deposited: 19 Sep 2017 10:01
Last Modified: 28 Aug 2021 15:35


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