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Effect of plasma surface treatment of poly(dimethylsiloxane) on the permeation of pharmaceutical compounds

Waters, Laura J. (2017) Effect of plasma surface treatment of poly(dimethylsiloxane) on the permeation of pharmaceutical compounds. Journal of Pharmaceutical Analysis, 7 (5). pp. 338-342. ISSN 2095-1779

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Abstract

This paper addresses the modification of poly(dimethylsiloxane), i.e. PDMS, using plasma surface treatment and a novel application of the membrane created. A set of model compounds were analysed to determine their permeation through PDMS, both with and without plasma treatment. It was found that plasma treatment reduced permeation for the majority of compounds but had little effect for some compounds, such as caffeine, with results indicating that polarity plays an important role in permeation, as is seen in human skin. Most importantly, a direct correlation was observed between plasma-modified permeation data and literature data through calculation of membrane permeability (Kp) values suggesting plasma-modified silicone membrane (PMSM) could be considered as a suitable in vivo replacement to predict clinical skin permeation.

Item Type: Article
Contributors:
ContributionNameEmailORCID
UNSPECIFIEDHemming, Karlk.hemming@hud.ac.ukUNSPECIFIED
UNSPECIFIEDfinch, catherinecatherine.finch@hud.ac.ukUNSPECIFIED
UNSPECIFIEDBhuiyan, A.K.M.M.H.UNSPECIFIEDUNSPECIFIED
UNSPECIFIEDMitchell, John C.UNSPECIFIEDUNSPECIFIED
Subjects: Q Science > QD Chemistry
Schools: School of Applied Sciences
Related URLs:
Depositing User: Laura Waters
Date Deposited: 15 Aug 2017 08:23
Last Modified: 28 Nov 2017 01:21
URI: http://eprints.hud.ac.uk/id/eprint/32803

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