Search:
Computing and Library Services - delivering an inspiring information environment

An evaluation of Minor Groove Binders as anti-lung cancer therapeutics

Scott, Fraser J., Puig-Sellart, Mireia, Khalaf, Abedawn I., Henderson, Catherine J., Westrop, Gareth, Watson, David G., Carter, Katharine, Grant, M. Helen and Suckling, Colin J. (2016) An evaluation of Minor Groove Binders as anti-lung cancer therapeutics. Bioorganic & Medicinal Chemistry Letters, 26 (15). pp. 3478-3486. ISSN 0960-894X

[img] PDF - Accepted Version
Restricted to Repository staff only until 16 June 2018.
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (1MB)

Abstract

A series of 47 structurally diverse MGBs, derived from the natural product distamycin, was evaluated for anti-lung cancer activity by screening against the melanoma cancer cell line B16-F10. Five compounds have been found to possess significant activity, more so than a standard therapy, Gemcitabine. Moreover, one compound has been found to have an activity around 70-fold that of Gemcitabine and has a favourable selectivity index of greater than 125. Furthermore, initial studies have revealed this compound to be metabolically stable and thus it represents a lead for further optimisation towards a novel treatment for lung cancer

Item Type: Article
Subjects: Q Science > QD Chemistry
Schools: School of Applied Sciences
Depositing User: Fraser Scott
Date Deposited: 15 Aug 2017 09:24
Last Modified: 15 Aug 2017 09:30
URI: http://eprints.hud.ac.uk/id/eprint/32646

Downloads

Downloads per month over past year

Repository Staff Only: item control page

View Item View Item

University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©