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Nail lacquer films’ surface energies and in vitro water-resistance and adhesion do not predict their in vivo residence

Murdan, Sudaxshina, Bari, Amani, Ahmed, Suleman, Hossin, Basma and Kerai, Laxmi (2017) Nail lacquer films’ surface energies and in vitro water-resistance and adhesion do not predict their in vivo residence. British Journal of Pharmacy, 2 (1). pp. 1-13. ISSN 2058-8356

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Abstract

The in vivo residence of nail lacquers (which are ideal topical drug carriers for the treatment of nail diseases) determines their frequency of application, and is thereby expected to influence patient adherence and success of treatment. Thus in vitro measurements to indicate lacquers’ in vivo residence are routinely conducted during formulation development. However the literature on in vitro-in vivo correlations is severely limited. Thus, the aim of the work discussed in this paper was to investigate correlations between in vivo residence and in vitro film resistance to water, in vitro film adhesion and surface energy of lacquer films. In vivo measurements were conducted on fingernails in six volunteers. Seven commercially available nail lacquers were tested in commonly-used measurements. Correlations between in vivo residence and in vitro water resistance and adhesion were found to be extremely poor. The surface energies of the lacquer films (which were between 33 and 39 mJ/m2) were also not predictive of in vivo residence. High density polyethylene (HDPE) sheet – whose surface energy was determined to be similar to that of the human nailplate – was found to be a suitable model for the nailplate (when investigating surface energy) and was used in a number of experiments.

Item Type: Article
Uncontrolled Keywords: nail, laquer, in-vitro in-vivo correlations
Subjects: R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
Schools: School of Applied Sciences
Depositing User: Megan Taylor
Date Deposited: 31 Jul 2017 08:49
Last Modified: 03 Aug 2017 11:25
URI: http://eprints.hud.ac.uk/id/eprint/32529

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