Search:
Computing and Library Services - delivering an inspiring information environment

The Emergence of New Psychoactive Substance (NPS) Benzodiazepines: A Review

Manchester, Kieran R., Lomas, Emma C., Waters, Laura J., Dempsey, Fiona C. and Maskell, Peter D. (2017) The Emergence of New Psychoactive Substance (NPS) Benzodiazepines: A Review. Drug Testing and Analysis. ISSN 1942-7603

[img] PDF - Accepted Version
Restricted to Repository staff only until 31 July 2018.

Download (1MB)

Abstract

The market for new psychoactive substances has increased markedly in recent years and there is now a steady stream of compounds appearing every year. Benzodiazepines consist of only a fraction of the total number of these compounds but their use and misuse has rapidly increased. Some of these benzodiazepines have only been patented, some of them have not been previously synthesised, and the majority have never undergone clinical trials or tests. Despite their structural and chemical similarity, large differences exist between the benzodiazepines in their pharmacokinetic parameters and metabolic pathways and so they are not easily comparable. As benzodiazepines have been clinically used since the 1960s, many analytical methods exist to quantify them in a variety of biological matrices and it is expected that these methods would also be suitable for the detection of benzodiazepines that are novel psychoactive substances. Illicitly obtained benzodiazepines have been found to contain a wide range of compounds such as opiates which presents a problem since the use of them in conjunction with each other can lead to respiratory depression and death. This review collates the available information on these benzodiazepines and provides a starting point for the further investigation of their pharmacokinetics which is clearly required.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Manchester, Kieran R., Lomas, Emma C., Waters, Laura J., Dempsey, Fiona C. and Maskell, Peter D. (2017) The Emergence of New Psychoactive Substance (NPS) Benzodiazepines: A Review. Drug Testing and Analysis. ISSN 1942-7603, which has been published in final form at http://dx.doi.org/10.1002/dta.2211. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Subjects: Q Science > QD Chemistry
Schools: School of Applied Sciences
Related URLs:
Depositing User: Laura Waters
Date Deposited: 30 Jun 2017 14:57
Last Modified: 06 Nov 2017 18:12
URI: http://eprints.hud.ac.uk/id/eprint/32340

Downloads

Downloads per month over past year

Repository Staff Only: item control page

View Item View Item

University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©