The Synthesis and Chemistry of Azolobenzodiazepines

Approaches to the synthesis and applications of the azolobenzodiazepines have been reviewed with a particular focus on the imidazo-, pyrrolo-, pyrazolo-, and triazolo-fused systems. The review covers N-arylation, metal-catalyzed coupling
processes, radiolabeled synthesis, multicomponent reactions, and the synthesis of biologically active molecules. Key natural products covered are the fuligocandins,the circumdatins, and other pyrrolobenzodiazepines. The review also covers well-known pharmaceutical substances such as flumazenil, midazolam, SJG-136, and alprazolam.