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Selective complexation of divalent cations by a cyclic α,β-peptoid hexamer: a spectroscopic and computational study.

De Santis, E., Edwards, A.A., Alexander, B.D., Holder, S.J., Biesse-Martin, A-S, Nielsen, B.V., Mistry, D., Waters, Laura J., Siligardi, G., Hussain, R., Faure, S. and Taillefumier, C. (2016) Selective complexation of divalent cations by a cyclic α,β-peptoid hexamer: a spectroscopic and computational study. Organic & Biomolecular Chemistry, 48. pp. 11371-11380. ISSN 1477-0520

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Abstract

We describe the qualitative and quantitative analysis of the complexation properties towards cations of a cyclic peptoid hexamer composed of alternating α- and β-peptoid monomers, which bear exclusively chiral (S)-phenylethyl side chains (spe) that have no noticeable chelating properties. The binding of a series of monovalent and divalent cations was assessed by 1H NMR, circular dichroism, fluorescence and molecular modelling. In contrast to previous studies on cations binding by 18-membered α-cyclopeptoid hexamers, the 21-membered cyclopeptoid cP1 did not complex monovalent cations (Na+, K+, Ag+) but showed selectivity for divalent cations (Ca2+, Ba2+, Sr2+ and Mg2+). Hexacoordinated C-3 symmetrical complexes were demonstrated for divalent cations with ionic radii around 1 Å (Ca2+ and Ba2+), while 5-coordination is preferred for divalent cations with larger (Ba2+) or smaller ionic radii (Mg2+).

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Schools: School of Applied Sciences
Related URLs:
Depositing User: Laura Waters
Date Deposited: 10 Jan 2017 14:34
Last Modified: 10 Jan 2017 15:34
URI: http://eprints.hud.ac.uk/id/eprint/30763

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