Fürstenberger, G., Epp, N., Eckl, K.M., Hennies, Hans C., Jorgensen, C., Hallenborg, P., Kristiansen, K. and Krieg, P. (2006) Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation. Prostaglandins Other Lipid Mediators, 82 (1-4). pp. 128-134.
Metadata only available from this repository.Abstract
12R-lipoxygenase (12R-LOX) and epidermis-type LOX-3 (eLOX-3) are novel members of the multigene family of mammalian LOX. A considerable gap exists between the identification of these enzymes and their biologic function. Here, we present evidence that 12R-LOX and eLOX-3, acting in sequence, and eLOX-3 in combination with another, not yet identified LOX are critically involved in terminal differentiation of keratinocytes and adipocytes, respectively. Mutational inactivation of 12R-LOX and/or eLOX-3 has been found to be associated with development of an inherited ichthyosiform skin disorder in humans and genetic ablation of 12R-LOX causes a severe impairment of the epidermal lipid barrier in mice leading to post-natal death of the animals. In preadipocytes, a LOX-dependent PPARγ activating ligand is released into the cell supernatant early upon induction of differentiation and available evidence indicates that this ligand is an eLOX-3-derived product. In accordance with this data is the observation that forced expression of eLOX-3 enhances adipocyte differentiation.
Item Type: | Article |
---|---|
Additional Information: | Unmapped bibliographic data: ST - Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation [Field not mapped to EPrints] LB - 10 [Field not mapped to EPrints] RP - Not in File [Field not mapped to EPrints] |
Uncontrolled Keywords: | Adipocytes |
Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics |
Schools: | School of Applied Sciences |
Related URLs: | |
Depositing User: | Hans Hennies |
Date Deposited: | 14 Jul 2016 11:08 |
Last Modified: | 28 Aug 2021 12:05 |
URI: | http://eprints.hud.ac.uk/id/eprint/28807 |
Downloads
Downloads per month over past year
Repository Staff Only: item control page
![]() |
View Item |