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Hillmer, A.M., Flaquer, A., Hanneken, S., Eigelshoven, S., Kortum, A.K., Brockschmidt, F.F., Golla, A., Metzen, C., Thiele, H., Kolberg, S., Reinartz, R., Betz, R.C., Ruzicka, T., Hennies, Hans C., Kruse, R. and Nöthen, M.M. (2008) Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26. American Journal of Human Genetics, 82 (3). pp. 737-743. ISSN 1537-6605
Metadata only available from this repository.Abstract
Androgenetic alopecia (AGA, male pattern baldness) is the most common form of hair loss. The origin of AGA is genetic, with the X chromosome located androgen receptor gene (AR) being the only risk gene identified to date. We present the results of a genome-wide linkage study of 95 families and linkage fine mapping of the 3q21-q29, 11q14-q25, 18p11-q23, and 19p13-q13 regions in an extended sample of 125 families of German descent. The locus with strongest evidence for linkage was mapped to 3q26 with a nonparametric linkage (NPL) score of 3.97 (empirical p value = 0.00055). This is the first step toward the identification of new susceptibility genes in AGA, a process which will provide important insights into the molecular and cellular basis of scalp hair loss.
| Item Type: | Article |
|---|---|
| Additional Information: | Unmapped bibliographic data: ST - Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26 [Field not mapped to EPrints] LB - 4 [Field not mapped to EPrints] RP - Not in File [Field not mapped to EPrints] |
| Uncontrolled Keywords: | Adult |
| Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics |
| Schools: | School of Applied Sciences |
| Related URLs: | |
| Depositing User: | Hans Hennies |
| Date Deposited: | 12 Jul 2016 10:00 |
| Last Modified: | 01 Apr 2018 18:15 |
| URI: | http://eprints.hud.ac.uk/id/eprint/28801 |
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