Palmoplantar keratoderma (PPK): acquired and genetic causes of a not so rare disease

Schiller, S., Seebode, C., Hennies, Hans C., Giehl, K. and Emmert, S. (2014) Palmoplantar keratoderma (PPK): acquired and genetic causes of a not so rare disease. Journal der Deutschen Dermatologischen Gesellschaft, 12 (9). pp. 781-788. ISSN 1610-0379

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Abstract

Palmoplantar keratodermas (PPK) comprise a heterogeneous group of keratinization disorders with hyperkeratotic thickening of palms and soles. Sporadic or acquired forms of PPKs and genetic or hereditary forms exist. Differentiation between acquired and hereditary forms is essential for adequate treatment and patient counseling. Acquired forms of PPK have many causes. A plethora of mutations in many genes can cause hereditary PPK. In recent years several new causative genes have been identified. Individual PPK may be quite heterogeneous with respect to presentation and associated symptoms. Since the various hereditary PPK - like many other monogenic diseases - exhibit a very low prevalence, making of the correct diagnosis is challenging and often requires a molecular genetic analysis. Knowledge about the large but quite heterogeneous group of hereditary PPK is also important to dissect the molecular mechanisms of epidermal differentiation on palms and soles, ultimately leading to targeted corrective therapies in the future.

Item Type:	Article
Additional Information:	Unmapped bibliographic data: ST - Palmoplantar keratoderma (PPK): acquired and genetic causes of a not so rare disease [Field not mapped to EPrints] AD - Department of Dermatology, Venereology, and Allergology, University Medical Center, Gottingen, Germany. [Field not mapped to EPrints] AN - 25176457 [Field not mapped to EPrints]
Uncontrolled Keywords:	Genetic Markers/genetics
Subjects:	Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics
Schools:	School of Applied Sciences
Depositing User:	Hans Hennies
Date Deposited:	06 Jul 2016 15:23
Last Modified:	29 Jul 2016 13:03
URI:	http://eprints.hud.ac.uk/id/eprint/28762

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