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Sefat, Farshid, Youseffi, Mansour, Khaghani, Seyed Ali, Soon, Chin Fhung and Javid, Farideh A. (2016) Effect of Transforming Growth Factor-β3 on mono and multilayer chondrocytes. Cytokine, 83. pp. 118-126. ISSN 1043-4666
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Abstract
Articular cartilage is an avascular and flexible connective tissue found in joints. It produces a cushioning effect at the joints and provides low friction to protect the ends of the bones from wear and tear/damage. It has poor repair capacity and any injury can result pain and loss of mobility. Transforming growth factor-beta (TGF-β), a cytokine superfamily, regulates cell function, including differentiation and proliferation. Although the function of the TGF-βs in various cell types has been investigated, their function in cartilage repair is as yet not fully understood. The effect of TGF-β3 in biological regulation of primary chondrocyte was investigated in this work. TGF-β3 provide fibroblastic morphology to chondrocytes and therefore overall reduction in cell proliferation was observed. The length of the cells supplemented with TGF-β3 were larger than the cells without TGF-β3 treatment. This was caused by the fibroblast like cells (dedifferentiated chondrocytes) which occupied larger areas compared to cells without TGF-β3 addition. The healing process of the model wound closure assay of chondrocyte multilayer was slowed down by TGF-β3, and this cytokine negatively affected the strength of chondrocyte adhesion to the cell culture surface.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Schools: | School of Applied Sciences |
| Related URLs: | |
| Depositing User: | Cherry Edmunds |
| Date Deposited: | 26 Apr 2016 12:34 |
| Last Modified: | 05 Aug 2017 06:01 |
| URI: | http://eprints.hud.ac.uk/id/eprint/28144 |
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