Pathobiology of chemotherapy-induced hair loss

Paus, Ralf, Haslam, Iain S., Sharov, Andrey A. and Botchkarev, Vladimir A. (2013) Pathobiology of chemotherapy-induced hair loss. The Lancet Oncology, 14 (2). e50-e59. ISSN 1474-5488

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Abstract

Hair loss can be a psychologically devastating adverse effect of chemotherapy, but satisfactory management strategies for chemotherapy-induced alopecia remain elusive. In this Review we focus on the complex pathobiology of this side-effect. We discuss the clinical features and current management approaches, then draw upon evidence from mouse models and human hair-follicle organ-culture studies to explore the main pathobiology principles and explain why chemotherapy-induced alopecia is so challenging to manage. P53-dependent apoptosis of hair-matrix keratinocytes and chemotherapy-induced hair-cycle abnormalities, driven by the dystrophic anagen or dystrophic catagen pathway, play important parts in the degree of hair-follicle damage, alopecia phenotype, and hair-regrowth pattern. Additionally, the degree of hair-follicle stem-cell damage determines whether chemotherapy-induced alopecia is reversible. We highlight the need for carefully designed preclinical research models to generate novel, clinically relevant pointers to how this condition may be overcome.

Item Type:	Article
Subjects:	Q Science > QH Natural history > QH301 Biology R Medicine > RL Dermatology
Schools:	School of Applied Sciences School of Applied Sciences > Biomolecular Sciences Research Centre
Depositing User:	Iain Haslam
Date Deposited:	11 Nov 2015 10:38
Last Modified:	11 Nov 2015 10:38
URI:	http://eprints.hud.ac.uk/id/eprint/26423

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