Sweeney, Joseph B., Gill, Duncan M., McLay, Neil, Waring, Michael and Wilkinson, Christopher Trevor (2014) An Improved Method for Difluorocyclopropanation of Alkenes. Synlett, 25 (12). pp. 1756-1758. ISSN 0936-5214

Difluorocyclopropanation of alkenes using fluorinated acetate salts using convential heating is often a slow, inefficient, and energy-intensive process. We report here a modified protocol which enables the rapid (<5 min) preparation of 1,1-difluorocyclopropanes, using microwave irradiation. The new procedure is not only considerably faster than previously reported methods, but it also employs easily removed, low boiling-point solvents and avoids the use of highly toxic or ozone-depleting substances.

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