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An Improved Method for Difluorocyclopropanation of Alkenes

Sweeney, Joseph B., Gill, Duncan M., McLay, Neil, Waring, Michael and Wilkinson, Christopher Trevor (2014) An Improved Method for Difluorocyclopropanation of Alkenes. Synlett, 25 (12). pp. 1756-1758. ISSN 0936-5214

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Difluorocyclopropanation of alkenes using fluorinated acetate salts using convential heating is often a slow, inefficient, and energy-intensive process. We report here a modified protocol which enables the rapid (<5 min) preparation of 1,1-difluorocyclopropanes, using microwave irradiation. The new procedure is not only considerably faster than previously reported methods, but it also employs easily removed, low boiling-point solvents and avoids the use of highly toxic or ozone-depleting substances.

Item Type: Article
Subjects: Q Science > QD Chemistry
Schools: School of Applied Sciences
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Depositing User: Joseph Sweeney
Date Deposited: 03 Nov 2015 10:01
Last Modified: 28 Aug 2021 11:56


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