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Mitochondrial DNA in Tumors

Lorenc, Anna, Bryk, Jarek and Bartnik, Ewa (2004) Mitochondrial DNA in Tumors. Toxicology Mechanisms and Methods, 14 (1-2). pp. 85-90. ISSN 1537-6516

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Mitochondria, cellular powerhouses, play a central role in apoptosis. In addition, they are suspected to contribute to aging. There is also increasing evidence that abnormalities in mitochondrial function help cancer development. Changes in mitochondrial transcription and oxidative phosphorylation pathways are observed in many types of cancer. Somatic mutations and quantitative changes in mitochondrial DNA were found in tumors, suggesting that alterations in mitochondrial DNA and the resulting respiratory deficiency play a role in carcinogenesis. It was postulated they could be useful as cancer markers. Mitochondria with abnormal functions are suitable targets for anticancer drugs.

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history
Q Science > QH Natural history > QH426 Genetics
Schools: School of Applied Sciences
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Depositing User: Sara Taylor
Date Deposited: 10 Sep 2015 13:09
Last Modified: 28 Aug 2021 11:54


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