Computing and Library Services - delivering an inspiring information environment

The Structure and Function of the Dopamine Transporter and its Role in CNS Diseases

McHugh, Patrick C and Buckley, David A. (2015) The Structure and Function of the Dopamine Transporter and its Role in CNS Diseases. In: Hormones and Transport Systems. Vitamins and the Immune System, 98 . Elsevier, pp. 339-369. ISBN 978-0-12-803008-0

Metadata only available from this repository.


In this chapter, we explore the basic science of the dopamine transporter (DAT), an integral component of a system that regulates dopamine homeostasis. Dopamine is a key neurotransmitter for several brain functions including locomotor control and reward systems. The transporter structure, function, mechanism of action, localization, and distribution, in addition to gene regulation, are discussed. Over many years, a wealth of information concerning the DAT has been accrued and has led to increased interest in the role of the DAT in a plethora of central nervous system diseases. These DAT characteristics are explored in relation to a range of neurological and neuropsychiatric diseases, with a particular focus on the genetics of the DAT. In addition, we discuss the pharmacology of the DAT and how this relates to disease and addiction.

Item Type: Book Chapter
Subjects: R Medicine > R Medicine (General)
Schools: School of Applied Sciences
Related URLs:
Depositing User: Cherry Edmunds
Date Deposited: 02 Jul 2015 15:19
Last Modified: 28 Aug 2021 11:52


Downloads per month over past year

Repository Staff Only: item control page

View Item View Item

University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©