Rhodium, Iridium, and Ruthenium Half-Sandwich Picolinamide Complexes as Anticancer Agents

Almodares, Zahra, Lucas, Stephanie J., Crossley, Benjamin D., Basri, Aida M., Pask, Christopher M., Hebden, Andrew J., Phillips, Roger M. and McGowan, Patrick C. (2014) Rhodium, Iridium, and Ruthenium Half-Sandwich Picolinamide Complexes as Anticancer Agents. Inorganic Chemistry, 53 (2). pp. 727-736. ISSN 0020-1669

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Abstract

Novel rhodium, iridium, and ruthenium half-sandwich complexes containing (N,N)-bound picolinamide ligands have been prepared for use as anticancer agents. The complexes show promising cytotoxicities, with the presence, position, and number of halides having a significant effect on the corresponding IC50 values. One ruthenium complex was found to be more cytotoxic than cisplatin on HT-29 and MCF-7 cells after 5 days and 1 h, respectively, and it remains active with MCF-7 cells even under hypoxic conditions, making it a promising candidate for in vivo studies.

Item Type:	Article
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Schools:	School of Applied Sciences
Related URLs:	Author
Depositing User:	Roger Phillips
Date Deposited:	12 May 2015 14:17
Last Modified:	14 May 2015 10:58
URI:	http://eprints.hud.ac.uk/id/eprint/24439

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