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Approaches to the synthesis of non-racemic 3-substituted isoindolinone derivatives

Allin, Steven M., Northfield, Christopher J., Page, Michael I. and Slawin, Alexandra M.Z. (2000) Approaches to the synthesis of non-racemic 3-substituted isoindolinone derivatives. Journal of the Chemical Society Perkin Transactions 1 (11). pp. 1715-1721. ISSN 14727781

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New methodology for the synthesis of non-racemic isoindolinone targets has been developed through application
of tricyclic γ-lactam substrates as N-acyliminium ion precursors in reactions with carbon and hydride nucleophiles.
Removal of the phenylglycinol derived chiral auxiliary can be achieved without loss of stereochemical integrity at
the newly created asymmetric centre, and we report a novel method for this key step using conc. sulfuric acid.

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Schools: School of Applied Sciences
School of Applied Sciences > Biomolecular Sciences Research Centre
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Depositing User: Sara Taylor
Date Deposited: 17 Oct 2008 10:58
Last Modified: 28 Aug 2021 10:42


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