Approaches to the synthesis of non-racemic 3-substituted isoindolinone derivatives

New methodology for the synthesis of non-racemic isoindolinone targets has been developed through application
of tricyclic γ-lactam substrates as N-acyliminium ion precursors in reactions with carbon and hydride nucleophiles.
Removal of the phenylglycinol derived chiral auxiliary can be achieved without loss of stereochemical integrity at
the newly created asymmetric centre, and we report a novel method for this key step using conc. sulfuric acid.