Allin, Steven M., Vaidya, Darshan G., Page, Michael I., Slawin, Alexandra M.Z. and Smith, Tim (2000) Highly diastereoselective synthesis and template manipulation of the thiazolo[2,3-a]isoindolin-1-one ring system. Tetrahedron Letters, 41 (13). pp. 2219-2222. ISSN 0040-4039
Metadata only available from this repository.Abstract
Condensation of 2-acetyl benzoic acid with -cysteine esters proceeds with extremely high diastereoselectivity to produce the desired thiazolo[2,3-a]isoindolin-1-one products in good yield. The relative stereochemistry of the major diastereoisomer has been determined by X-ray crystallography. Stereoselective enolate alkylation of this substrate has been investigated as a method to manipulate the ring skeleton, and was found to proceed with up to exclusive levels of stereoselectivity
Item Type: | Article |
---|---|
Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
Schools: | School of Applied Sciences School of Applied Sciences > Biomolecular Sciences Research Centre |
Related URLs: | |
Depositing User: | Sara Taylor |
Date Deposited: | 17 Oct 2008 10:22 |
Last Modified: | 28 Aug 2021 10:42 |
URI: | http://eprints.hud.ac.uk/id/eprint/2263 |
Downloads
Downloads per month over past year
Repository Staff Only: item control page
![]() |
View Item |