Page, Michael I. and Laws, Andrew P. (2000) The Chemical Reactivity of β-Lactams, β-Sultams and β-Phospholactams. Tetrahedron, 56 (31). pp. 5631-5637. ISSN 0040-4020

β-Lactam antibiotics display a range of biological activities. The origin of this diverse biological activity is discussed with reference to the chemical reactivity of the small ring system. The reactions of β-sultams and β-phospholactams with simple nucleophiles are reported and their potential as mechanism based inhibitors of bacterial and mammalian serine proteases is described.

Add to AnyAdd to TwitterAdd to FacebookAdd to LinkedinAdd to PinterestAdd to Email