Computing and Library Services - delivering an inspiring information environment

Nanoscale crystallinity modulates cell proliferation on plasma sprayed surfaces

Smith, Alan M., Paxton, Jennifer Z, Hung, Yi-Pei, Hadley, Martin J., Bowen, James, Williams, Richard L. and Grover, Liam M. (2015) Nanoscale crystallinity modulates cell proliferation on plasma sprayed surfaces. Materials Science and Engineering: C, 48. pp. 5-10. ISSN 09284931

[img] PDF - Accepted Version
Download (1MB)


Calcium phosphate coatings have been applied to the surface of metallic prostheses to mediate
hard and soft tissue attachment for more than 40 years. Most coatings are formed of high purity
hydroxyapatite, and coating methods are often designed to produce highly crystalline surfaces. It
is likely however, that coatings of lower crystallinity can facilitate more rapid tissue attachment
since the surface will exhibit a higher specific surface area and will be considerably more
reactive than a comparable highly crystalline surface. Here we test this hypothesis by growing a
population of MC3T3 osteoblast-like cells on the surface of two types of hip prosthesis with
similar composition, but with differing crystallinity. The surfaces with lower crystallinity
facilitated more rapid cell attachment and increased proliferation rate, despite having a less
heterogeneous surface topography. This work highlights that the influence of the crystallinity of
HA at the nano-scale is dominant over macro-scale topography for cell adhesion and growth.
Furthermore, crystallinity could be easily adjusted by without compromising coating purity.
These findings could facilitate designing novel coated calcium phosphate surfaces that more
rapidly bond tissue following implantation.

Item Type: Article
Subjects: Q Science > QD Chemistry
R Medicine > RD Surgery
R Medicine > RS Pharmacy and materia medica
T Technology > T Technology (General)
Schools: School of Applied Sciences
Related URLs:
Depositing User: Alan Smith
Date Deposited: 27 Nov 2014 16:34
Last Modified: 28 Aug 2021 18:45


Downloads per month over past year

Repository Staff Only: item control page

View Item View Item

University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©