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A One-Pot Aza-Wittig Based Solution and Polymer Supported Route to Amines

Hemming, Karl, Bevan, Matthew J., Loukou, Christina, Patel, Snahal D. and Renaudeau, Denis (2000) A One-Pot Aza-Wittig Based Solution and Polymer Supported Route to Amines. Synlett, 2000 (11). pp. 1565-1568. ISSN 09365214

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This paper presents a high yielding one-pot solution phase and polymer supported synthesis of a range of primary and secondary amines starting from azides and aldehydes. The synthesis utilises a tandem process which begins with an aza-Wittig reaction between the aldehyde and an iminophosphorane, followed by reduction, or organometallic 1,2-addition reaction, of the resultant imine. The requisite iminophosphoranes were accessed using the highly efficient Staudinger reaction between the azide starting material and a phosphine. The process was applicable to the solid phase by the use of polymer supported iminophosphoranes and polymer supported cyanoborohydride

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Schools: School of Applied Sciences
School of Applied Sciences > Biomolecular Sciences Research Centre
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Depositing User: Sara Taylor
Date Deposited: 16 Oct 2008 11:21
Last Modified: 28 Aug 2021 10:42


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