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Synthesis of Highly Substituted Pyrroles via Nucleophilic Catalysis.

Ngwerume, Simbarashe and Camp, Jason (2010) Synthesis of Highly Substituted Pyrroles via Nucleophilic Catalysis. Journal of Organic Chemistry, 75 (18). pp. 6271-6274. ISSN 0022-3263

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A nucleophilic catalysis method providing a concise synthesis of di-, tri-, and tetrasubstituted pyrroles is described. This regioselective one-pot method relies on nucleophilic catalysis of the intermol. addn. of oximes to activated alkynes and thermal rearrangement of the in situ generated O-vinyl oximes to form pyrroles that contain a functional group handle at the C3/C4 position. [on SciFinder(R)]

Item Type: Article
Additional Information: Unmapped bibliographic data: PY - 2010/// [EPrints field already has value set] M3 - 10.1021/jo1011448 [Field not mapped to EPrints] JA - J. Org. Chem. [Field not mapped to EPrints]
Uncontrolled Keywords: oxime stereoselective prepn, ketone hydroxyamine hydrochloride diastereoselective condensation, pyrrole prepn, alkyne oxime regioselective intermol addn nucleophilic catalysis, vinyl oxime thermal rearrangement microwave irradn
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Schools: School of Applied Sciences
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Depositing User: Sara Taylor
Date Deposited: 13 Nov 2014 16:46
Last Modified: 28 Aug 2021 11:43


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