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Identification of Native American Founder mtDNAs Through the Analysis of Complete mtDNA Sequences: Some Caveats

Bandelt, Hans-Jürgen, Herrnstadt, C., Yao, Y.-G., Kong, Q.-P., Kivisild, T., Rengo, C., Scozzari, R., Richards, Martin B., Villems, R., Macaulay, V., Howell, N., Torroni, A. and Zhang, Y.-P. (2003) Identification of Native American Founder mtDNAs Through the Analysis of Complete mtDNA Sequences: Some Caveats. Annals of Human Genetics, 67 (6). pp. 512-524. ISSN 00034800

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In this study, a detailed analysis of both previously published and new data was performed to determine whether complete, or almost complete, mtDNA sequences can resolve the long-debated issue of which Asian mtDNAs were founder sequences for the Native American mtDNA pool. Unfortunately, we now know that coding region data and their analysis are not without problems. To obtain and report reasonably correct sequences does not seem to be a trivial task, and to discriminate between Asian and Native American mtDNA ancestries may be more complex than previously believed. It is essential to take into account the effects of mutational hot spots in both the control and coding regions, so that the number of apparent Native American mtDNA founder sequences is not erroneously inflated. As we report here, a careful analysis of all available data indicates that there is very little evidence that more than five founder mtDNA sequences entered Beringia before the Last Glacial Maximum and left their traces in the current Native American mtDNA pool.

Item Type: Article
Subjects: E History America > E11 America (General)
Q Science > Q Science (General)
Q Science > QH Natural history > QH426 Genetics
Schools: School of Applied Sciences
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Depositing User: Sara Taylor
Date Deposited: 12 Aug 2014 14:22
Last Modified: 28 Aug 2021 11:41


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