Computing and Library Services - delivering an inspiring information environment

Single, rapid coastal settlement of Asia revealed by analysis of complete mitochondrial genomes

Macaulay, Vincent, Hill, Catherine, Achilli, Alessandro, Rengo, Chiara, Clarke, Douglas, Meehan, William, Blackburn, James, Semino, Ornello, Scozzari, Rosaria, Cruciani, Fulvio, Taha, Adi, Shaari, Norazila Kassim, Raja, Joseph Maripa, Ismail, Patimah, Zainuddin, Zafarina, Goodwin, William, Bulbeck, David, Bandelt, Hans-Jurgen, Oppenheimer, Stephen, Torroni, Antonio and Richards, Martin B. (2005) Single, rapid coastal settlement of Asia revealed by analysis of complete mitochondrial genomes. Science, 308 (5724). pp. 1034-1036. ISSN 0036-8075

[img] PDF
Restricted to Registered users only

Download (139kB)


A recent dispersal of modern humans out of Africa is now widely accepted, but the routes taken across Eurasia are still disputed. We show that mitochondrial DNA variation in isolated "relict" populations in southeast Asia supports the view that there was only a single dispersal from Africa, most likely via a southern coastal route, through India and onward into southeast Asia and Australasia. There was an early offshoot, leading ultimately to the settlement of the Near East and Europe, but the main dispersal from India to Australia 65,000 years ago was rapid, most likely taking only a few thousand years

Item Type: Article
Additional Information: c 2005 by the American Association for the Advancement of Science;
Uncontrolled Keywords: populations asia africa dispersal settlement mitochondrial genomes
Subjects: G Geography. Anthropology. Recreation > G Geography (General)
G Geography. Anthropology. Recreation > GF Human ecology. Anthropogeography
Schools: School of Applied Sciences
References: 1. C. B. Stringer, P. Andrews, Science 239, 1263 (1988). 2. F. Prugnolle, A. Manica, F. Balloux, Curr. Biol. 15, R159 (2005). 3. L. L. Cavalli-Sforza, P. Menozzi, A. Piazza, The History and Geography of Human Genes (Princeton Univ. Press, Princeton, NJ, 1994). 4. M. M. Lahr, R. Foley, Evol. Anthropol. 3, 48 (1994). 5. L. Quintana-Murci et al., Nat. Genet. 23, 437 (1999). 6. N. Maca-Meyer, A. M. Gonza´lez, J. M. Larruga, C. Flores, V. M. Cabrera, BMC Genet. 2, 13 (2001). 7. M. Tanaka et al., Genome Res. 14, 1832 (2004). 8. R. Lewin, R. A. Foley, Principles of Human Evolution (Blackwell, Oxford, ed. 2, 2004). 9. M. Nei, A. K. Roychoudhury, Mol. Biol. Evol. 10, 927 (1993). 10. L. Vigilant, M. Stoneking, H. Harpending, K. Hawkes, A. C. Wilson, Science 253, 1503 (1991). 11. E. Watson, P. Forster, M. Richards, H.-J. Bandelt, Am. J. Hum. Genet. 61, 691 (1997). 12. P. Forster, A. Torroni, C. Renfrew, A. Ro¨hl, Mol. Biol. Evol. 18, 1864 (2001). 13. P. Endicott et al., Am. J. Hum. Genet. 72, 178 (2003). 14. P. Endicott, V. Macaulay, T. Kivisild, C. Stringer, A. Cooper, Am. J. Hum. Genet. 72, 1590 (2003). 15. T. Kivisild et al., Am. J. Hum. Genet. 72, 313 (2003). 16. M. Metspalu et al., BMC Genet. 5, 26 (2004). 17. R. C. Walter et al., Nature 405, 65 (2000). 18. R. Cordaux, M. Stoneking, Am. J. Hum. Genet. 72, 1586 (2003). 19. P. Bellwood, Asian Perspect. 32, 37 (1993). 20. P. Bellwood, Prehistory of the Indo-Malaysian Archipelago (Univ. of Hawaii Press, Honolulu, 1997). 21. D. Bulbeck, in Under the Canopy: The Archaeology of Tropical Rain Forests, J. Mercader, Ed. (Rutgers Univ. Press, New Brunswick, NJ, 2003), pp. 119–160. 22. D. Mishmar et al., Proc. Natl. Acad. Sci. U.S.A. 100, 171 (2003). 23. P. Forster, Philos. Trans. R. Soc. London Ser. B 359, 255 (2004). 24. M. G. Palanichamy et al., Am. J. Hum. Genet. 75, 966 (2004). 25. Q.-P. Kong et al., Am. J. Hum. Genet. 73, 671 (2003); erratum, Am. J. Hum. Genet. 75, 157 (2004). 26. T. H. van Andel, P. C. Tzedakis, Quat. Sci. Rev. 15, 481 (1996). 27. See supporting data on Science Online. 28. Y.-G. Yao, Q.-P. Kong, H.-J. Bandelt, T. Kivisild, Y.-P. Zhang, Am. J. Hum. Genet. 70, 635 (2002). 29. M. Ingman, U. Gyllensten, Genome Res. 13, 1600 (2003). 30. C. S. M. Turney et al., Quat. Res. 55, 3 (2001). 31. G. Barker et al., Proc. Prehist. Soc. 68, 147 (2002). 32. L. Hazelwood, J. Steele, J. Archaeol. Sci. 31, 669 (2004). 33. R. A. Housley, C. S. Gamble, M. Street, P. Pettitt, Proc. Prehist. Soc. 63, 25 (1997). 34. M. Richards et al., Am. J. Hum. Genet. 67, 1251 (2000). 35. S. McBrearty, A. S. Brookes, J. Hum. Evol. 39, 453 (2000). 36. Supported by United Productions and the Discovery Channel, the British Academy, the Royal Society, the University of Huddersfield, the Wellcome Trust, the Italian Ministry of the University (Progetti Ricerca Interesse Nazionale 2003), Progetto CNR-MIUR Genomica Funzionale-Legge 449/97, Grandi Progetti di Ateneo (Universita` La Sapienza), the Muzium Negara Malaysia (Kuala Lumpur), and the Universiti Putra Malaysia. We thank the Malaysian participants for providing cheek-swab samples and J. Clegg and A. S. Sofro for Indonesian samples.
Depositing User: Sara Taylor
Date Deposited: 20 Dec 2007
Last Modified: 28 Aug 2021 23:35


Downloads per month over past year

Repository Staff Only: item control page

View Item View Item

University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©