Wright, Josephine A., McHugh, Patrick C, Pan, Siyi, Cunningham, Adam and Brown, David .R. (2013) Counter-regulation of alpha- and beta-synuclein expression at the transcriptional level. Molecular and Cellular Neuroscience, 57. pp. 33-41. ISSN 1044-7431
Metadata only available from this repository.Abstract
Alpha-synuclein is a cytosolic protein associated with a range of diseases including Parkinson's disease. In these diseases alpha-synuclein aggregates and this is believed to play a causative role in disease progression. Alpha-synuclein aggregation has been suggested to be caused by increased expression levels and has also been suggested to be countered by increased beta-synuclein expression. In this regard, strategies to counter-regulate the expression of the synucleins by increasing beta-synuclein expression relative to alpha-synuclein may be beneficial in preventing disease progression. We therefore studied the regulation of alpha-synuclein to try to identify pathways that might counter-regulate the synucleins. We identified members of the ZSCAN family of transcription factors as specific repressors of alpha-synuclein. In particular ZSCAN21 was found to both repress alpha-synuclein and increase beta-synuclein expression. These findings support the notion that a single pathway in the cell can counter-regulate the expression of the synucleins. Support for this came from experiments that showed that ZSCAN21 expression decreases alpha-synuclein aggregation in the cells.
Item Type: | Article |
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Subjects: | R Medicine > RS Pharmacy and materia medica |
Schools: | School of Applied Sciences |
Related URLs: | |
Depositing User: | Cherry Edmunds |
Date Deposited: | 28 Jan 2014 14:59 |
Last Modified: | 28 Aug 2021 11:35 |
URI: | http://eprints.hud.ac.uk/id/eprint/19539 |
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