Javid, Farideh A. and Palea, Stefano (2014) The effect of 5-HT and electrical field stimulation on the contractility of the whole isolated urinary bladder of Suncus murinus. European Journal of Pharmacology, 723. pp. 489-493. ISSN 0014-2999
Metadata only available from this repository.Abstract
The present study used the whole isolated urinary bladder of Suncus murinus, to investigate the effect of exogenously added serotonin (5-HT) and electrical field stimulation (EFS) in the absence and presence of methysergide, a 5-HT1/2/7 receptor antagonist or the selective 5-HT7 receptor antagonist, SB269970. Further experiments investigated the involvement of potassium channel, cholinergic and purinergic systems in mediating the contractile response to EFS. Pre-treatment with methysergide reduced and increased the contractile responses to 5-HT and EFS, respectively. Pre-treatment with SB269970 increased the responses to 5-HT without modifying the EFS-induced contractions. EFS-induced contractions were not modified by pre-treatment with atropine (10 μM), α-β-methylene ATP or glibenclamide. EFS-induced contractions were attenuated by cromakalim or atropine (<1 μM). In conclusion, the 5-HT2 receptors are likely to play a role in mediating the contractile response to 5-HT in detrusor muscle. Furthermore, EFS-induced contractions are mediated through cholinergic and an unknown neurotransmitter which is modulated by K(ATP ) channels in the detrusor muscle of Suncus murinus.
Item Type: | Article |
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Subjects: | R Medicine > RS Pharmacy and materia medica |
Schools: | School of Applied Sciences |
Related URLs: | |
Depositing User: | Cherry Edmunds |
Date Deposited: | 28 Oct 2013 12:18 |
Last Modified: | 04 Apr 2018 12:00 |
URI: | http://eprints.hud.ac.uk/id/eprint/19012 |
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