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Oxadiazole isomers: all bioisosteres are not created equal

Goldberg, Kristin, Groombridge, Sam, Hudson, Julian, Leach, Andrew G., MacFaul, Philip A., Pickup, Adrian, Poultney, Ruth, Scott, James S., Svensson, Per H. and Sweeney, Joseph B. (2012) Oxadiazole isomers: all bioisosteres are not created equal. MedChemComm, 3 (5). p. 600. ISSN 2040-2503

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Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.

Item Type: Article
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Schools: School of Applied Sciences
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Depositing User: Joseph Sweeney
Date Deposited: 18 Oct 2012 12:16
Last Modified: 28 Aug 2021 11:22


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