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The effect of different storage temperatures on the physical properties of pectin solutions and gels

Morris, Gordon, Castile, Jonathan, Smith, Alan, Adams, Gary and Harding, Stephen E. (2010) The effect of different storage temperatures on the physical properties of pectin solutions and gels. Polymer Degradation and Stability, 95 (12). pp. 2670-2673. ISSN 0141-3910

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The stability (in terms of viscosity and gel strength) of pectin solutions and gels potentially plays an important role in their behaviour and functional properties in a wide range of applications and therefore any changes over time must be understood. The gel strength of pectin gels and intrinsic viscosity of pectin solutions at different temperatures (4 °C, 25 °C and 40 °C) have been investigated using a "rolling ball" viscometer and a texture analyser respectively. Both the intrinsic viscosity ([η]) and gel strength decrease with increased storage time, although this more pronounced at elevated temperatures. The changes in intrinsic viscosity with storage time and temperature were used to determine the depolymerisation constant (k). Pectin storage conditions and particularly temperature have an influence on depolymerisation, particularly elevated storage temperatures, but whether or not this will be detrimental to its intended application will depend on the functional significance of the changes that occur. In this case based on the previous diffusion studies on a model drug (paracetamol) we conclude that the decreases in viscosity and gel strength within the range observed have no detrimental effect on the drug release properties.© 2010 Elsevier Ltd. All rights reserved.

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Item Type: Article
Additional Information: NOTICE: this is the author’s version of a work that was accepted for publication in Polymer Degradation and Stability Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Polymer Degradation and Stability Volume 95, Issue 12, December 2010, Pages 2670–2673
Uncontrolled Keywords: Drug release Gel strength Intrinsic viscosity Molar mass Pectin Stability Case based Detrimental effects Diffusion studies Drug release properties Elevated temperature Functional properties Gel strengths Model drugs Paracetamol Rolling balls Storage condition Storage temperatures Storage time Drug products Gels Viscometers Viscosity
Subjects: Q Science > QD Chemistry
Schools: School of Applied Sciences
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References: Language of Original Document: English Correspondence Address: Morris, G. A.; Division of Food Sciences, School of Biosciences, University of Nottingham, Sutton Bonington LE12 5RD, United Kingdom; email: References: Van Buren, J.P., Function of pectin in plant tissue structure and firmness (1991) The Chemistry and Technology of Pectin, p. 1; Tombs, M.P., Harding, S.E., (1998) Polysaccharide Biotechnology, , Taylor Francis London; Mohnen, D., Pectin structure and biosynthesis (2008) Curr Opin Plant Biol, 11, pp. 266-277; Ridley, B.L., O'Neil, M.A., Mohnen, D., Pectins: Structure, biosynthesis and oligogalacturonide-related signalling (2001) Phytochemistry, 57, pp. 929-967; Willats, W.G.T., McCartney, L., MacKie, W., Knox, J.P., Pectin: Cell biology and prospects for functional analysis (2001) Plant Mol Biol, 47, pp. 9-27; Mohnen, D., Pectin structure and biosynthesis (2008) Curr Opin Plant Biol, 11, pp. 266-277; Pilgrim, G.W., Walter, R.H., Oakenfull, D.G., The chemistry of high-methoxyl pectins (1991) The Chemistry and Technology of Pectin, p. 24; Powel, D.A., Morris, E.R., Gidley, M.J., Rees, D.A., Conformations and interactions of pectins ii. Influence of residue sequence on chain association in calcium pectate gels (1982) J Mol Biol, 153, pp. 517-531; Axelos Mav Branger, M., The effect of the degree of esterification on the thermal-stability and chain conformation of pectins (1993) Food Hydrocolloid, 7, pp. 91-102; Lui, L., Fishman, M.L., Hicks, K.B., Pectin in controlled drug delivery - A review (2007) Cellulose, 14, pp. 15-24; Lui, L., Fishman, M.L., Kost, J., Hicks, K.B., Pectin-based systems for colon-specific drug delivery via oral route (2003) Biomaterials, 24, pp. 3333-3343; Sungthongjeen, S., Sriamornsak, P., Pitaksuteepong, T., Somsiri, A., Puttipipatkhachorn, S., Effect of degree of esterification of pectin and calcium amount on drug release from pectin-based matrix tablets (2004) AAPS Pharm Sci Tech, 5, pp. 1-9; Thirowong, N., Kennedy, R.A., Sriamornsak, P., Viscometric study of pectin-mucin interaction and its mucoadhesive bond strength (2007) Carbohyd Polym, 71, pp. 170-179; Yadav, N., Morris, G.A., Harding, S.E., Ang, S., Adams, G.G., Various non-injectable delivery systems for the treatment of diabetes mellitus (2009) Endocrine Metab Immune Disord - Drug Targets, 9, pp. 1-13; Morris, G.A., García De La Torre, J., Ortega, A., Castille, J., Smith, A., Harding, S.E., Molecular flexibility of citrus pectins by combined sedimentation and viscosity analysis (2008) Food Hydrocolloid, 22, pp. 1435-1442; Solomon, O.F., Ciutâ, I.Z., Détermination de la viscosité intrinsque de solutions de polymres par une simple détermination de la viscosité (1962) J Appl Polym Sci, 24, pp. 683-686; Harding, S.E., Berth, G., Ball, A., Mitchell, J.R., Garca De La Torre, J., The molecular weight distribution and conformation of citrus pectins in solution studied by hydrodynamics (1991) Carbohyd Polym, 168, pp. 1-15; Cros, S.C., Garnier, C., Axelos, M.A.V., Imbery, A., Perez, S., Solution conformations of pectin polysaccharides: Determination of chain characteristics by small angle neutron scattering, viscometry and molecular modeling (1996) Biopolymers, 39, pp. 339-352; Morris, G.A., Foster, T.J., Harding, S.E., The effect of degree of esterification on the hydrodynamic properties of citrus pectin (2000) Food Hydrocolloid, 14, pp. 227-235; Ralet, M.-C., Bonnin, E., Thibault, J.-F., Chromatographic study of highly methoxylated lime pectins de-esterified by different pectin methyl-esterases (2001) J Chromatogr B, 753, pp. 157-166; Morris, G.A., Foster, T.J., Harding, S.E., A hydrodynamic study of the depolymerisation of a high methoxy pectin at elevated temperatures (2002) Carbohyd Polym, 48, pp. 361-367; Yoo, S.-H., Fishman, M.L., Hotchkiss, A.T., Lee, H.G., Viscometric behavior of high-methoxy and low-methoxy pectin solutions (2006) Food Hydrocolloid, 20, pp. 62-67; Axelos, M.A.V., Thibault, J.F., The chemistry of low-methoxyl pectin gelation (1991) The Chemistry and Technology of Pectin, p. 109; Morris, G.A., Butler, S.N.G., Foster, T.J., Jumel, K., Harding, S.E., Elevated temperature analytical ultracentrifugation of low-methoxy polyuronide (1999) Prog Coll Pol Sci, 113, pp. 205-208; Zhou, G., Yao, W., Wang, C., Kinetics of microwave degradation of λ-carrageenan from Chondrus ocellatus (2006) Carbohyd Polym, 64, pp. 73-77; Norziah, M.H., Fang, E.O., Abd Karim, A., Extraction and characterisation of pectin from pomelo peels (2000) Gums and Stabilisers for the Food Industry, 10, p. 27; Chelladurai, S., Mishra, M., Mishra, B., Design and evaluation of bioadhesive in-situ nasal gel of ketorolac tromethamine (2008) Chem Pharm Bull, 56, pp. 1596-1599; Nessa, M.U., (2003) Physiochemical Characterisation of Pectin Solution As A Vehicle for Nasal Drug Delivery, , MSc Dissertation, University of Nottingham, U.K
Depositing User: Gordon Morris
Date Deposited: 13 Sep 2012 14:28
Last Modified: 28 Aug 2021 20:32

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