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Scale-up – How do we get it right first time?

Atherton, John H and Hall, Alan (2011) Scale-up – How do we get it right first time? Chemistry Today, 29 (4). pp. 47-49. ISSN 0392-839X

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Scale-up in the context of fast moving process development can be problematic. Getting scale up right requires an understanding of the way in which physical and chemical process parameters interact to determine overall performance. Multiphase systems are particularly difficult. The most common types of scale up problem at the reaction stage will be shown, and the root causes will be discussed and exemplified. Common root causes are: increases in overall processing time on scale-up, with possible adverse effects on yield and quality; differences in heat transfer capability, which can feed back to increases in cycle time; changes in mass transfer rates, which can impact on reaction time and selectivity; poor dispersion of solids (mass transport), leading low reaction rates and stalled reactions; and changes in mixing efficiency in homogeneous reactions, with implications for reaction selectivity. A procedure for identification of potential scale-up problems will be described.

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Item Type: Article
UNSPECIFIEDHall, Alanalan.hall@gmx.comUNSPECIFIED
Uncontrolled Keywords: Scale-up
Subjects: Q Science > QD Chemistry
Schools: School of Applied Sciences
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References: 1. Bisio, R.L. Kabel, Scaleup of Chemical Processes, John Wiley & Sons,1985. 2. G. Caygill, M. Zanfir et al., Org. Process Res. Dev., 10, pp. 539-552(2006). 3. F.L Muller, J.M. Latimer, Proceedings of European Congress of Chemical Engineering (ECCE-6), Copenhagen Sept. 2007. 4. J.H. Atherton, K.J. Carpenter, Process Development: Physicochemical Concepts, OUP (1999). 5. I . Houson (ed.), Process understanding, Wiley-VCH (2011). 6. A .J. Blacker, M.T. Williams, (ed.) Pharmaceutical Process Development: Current Chemical and Engineering Challenges, pub. Royal Society of Chemistry, Cambridge (2011). 7. J.R. Bourne, Org. Process Res. Dev., 7, pp. 471-508 (2003). 8. J. Baldyga, J.R. Bourne et al., Can. J. Chem. Eng., 17, pp. 641-649 (1998). 9. J.H. Atherton, J.M. Double et al., paper presented to World Congress of Chemical Engineering, Glasgow 2005. 10. J.D. Moseley, P. Bansal et al., Organic Process Research and Development, 10, pp. 153-158 (2006). 11. J. Leonard, AZD6244: challenges of route design and development,28th SCI Process Development Symposium, December 2010. 12. E .L. Paul, V.A. Atiemo-Obeng et al., Handbook of Industrial Mixing, p. 546, Wiley-Interscience (2004). 13. K.M.J. Brands, S.W. Krska et al., Org.Process Res. Dev., 10, pp. 109-117 (2006). 14. J.H. Atherton, A. Hall, unpublished work.
Depositing User: John Atherton
Date Deposited: 15 May 2012 15:36
Last Modified: 28 Aug 2021 20:52


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