Camps, Pelayo, Contreras, Joan, El Achab, Rachid, Morral-Cardoner, Jordi, Muñoz-Torrero, Diego, Font-Bardia, Mercè, Solans, Xavier, Badia, Albert and Vivas, Nuria María (2000) New Syntheses of rac-Huperzine A and its rac-7-Ethyl-Derivative. Evaluation of Several Huperzine A Analogues as Acetylcholinesterase Inhibitors. Tetrahedron, 56 (26). pp. 4541-4553. ISSN 0040-4020
Metadata only available from this repository.Abstract
rac-Huperzine A, its rac-7-ethyl-derivative and two regioisomeric analogues have been prepared through synthetic sequences involving the elaboration of the pyridone ring in a late stage, by reaction of an intermediate pyrrolidine enamine with propiolamide, which gave mixtures of regioisomeric pyridone derivatives. The acetylcholinesterase inhibitory activity of these and two other recently described 11-unsubstituted huperzine A analogues was determined, the rac-7-ethyl analogue of huperzine A being the most active compound, although it is about 12-fold less active than (−)-huperzine A.
Item Type: | Article |
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Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
Schools: | School of Applied Sciences |
Related URLs: | |
Depositing User: | Sara Taylor |
Date Deposited: | 28 Jun 2011 15:55 |
Last Modified: | 28 Aug 2021 11:08 |
URI: | http://eprints.hud.ac.uk/id/eprint/10816 |
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