Computing and Library Services - delivering an inspiring information environment

Molecular flexibility of methylcelluloses of differing degree of substitution by combined sedimentation and viscosity analysis

Patel, T. R., Morris, Gordon, Garcia de la Torre, J., Ortega, A., Mischnick, P. and Harding, S. E. (2008) Molecular flexibility of methylcelluloses of differing degree of substitution by combined sedimentation and viscosity analysis. Macromolecular Bioscience, 8 (12). pp. 1108-1115. ISSN 1616-5187

[img] PDF - Accepted Version
Restricted to Registered users only

Download (869kB)


The flexibility/rigidity of methylcelluloses (MCs) plays an important part in their structure-function relationship and therefore on their commercial applications in the food and biomedical industries. In the present study, two MCs of low degree of substitution (DS) 1.09 and 1.32 and four of high DS (1.80, 1.86, 1.88 and 1.93) were characterised in distilled water in terms of intrinsic viscosity [η]; sedimentation coefficient (s20,w0) and weight average molar mass (M̄w). Solution conformation and flexibility were estimated qualitatively using conformation zoning and quantitatively (persistence length Lp) using the new combined global method. Sedimentation conformation zoning showed an extended coil (Type C) conformation and the global method applied to each MC sample yielded persistence lengths all within the range Lp = 12-17 nm (for a fixed mass per unit length) with no evidence of any significant change in flexibility with DS. A graph is presented. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Item Type: Article
Uncontrolled Keywords: Conformational analysis Intrinsic viscosity Methylcellulose Molar mass Persistence length Sedimentation coefficient Dielectric relaxation Land use Sedimentation Viscosity Zoning Conformations article chemistry conformation high performance liquid chromatography molecular weight structure activity relation ultracentrifugation Chromatography, High Pressure Liquid Molecular Conformation Structure-Activity Relationship
Subjects: Q Science > QD Chemistry
Schools: School of Applied Sciences
Related URLs:
References: Language of Original Document: English Correspondence Address: Harding, S.E.; National Center for Macromolecular Hydrodynamics, School of Biosciences, University of Nottingham, Sutton Bonington LE12 5RD, United Kingdom; email: Chemicals/CAS: methylcellulose, 79484-92-7, 9004-67-5; Methylcellulose, 9004-67-5 References: Haworth, W.N., (1928) Helv. Chim. Acta, 11, p. 534; Staudinger, H., (1932) Die hochmolekularen organischen Verbindungen - Kautschuk und Cellulose, , Springer Verlag, Heidelberg; Gralén, N., Sedimentation and Diffusion Measurements on Cellulose and Cellulose Derivatives (1944), PhD Dissertation, University of Uppsala, SwedenPeterlin, A., (1952) J. Polym. Sci, 8, p. 173; Kim, J., Yun, S., Ounaies, Z., (2006) Macromolecules, 39, p. 4202; Clasen, C., Kulicke, W.-M., (2001) Prog. Polym. Sci, 26, p. 1839; Krässig, H., Schurz, J., Steadman, R.G., Schliefer, K., Albrecht, W., Mohring, M., Schlosser, M., Cellulose (2004) Ullmann's Encyclopedia of Industrial Chemistry, p. 375. , 7th edition, W. Gerhartz, Ed, Wiley-VCH, Weinheim; Brandt, L., Hoechst, A.G., Kalle, N., Cellulose Ethers (2000) Ullmann's Encyclopedia of Industrial Chemistry, p. 461. , 5th edition, H.-J. Arpe, Ed, Wiley-VCH, Weinheim; Cheetham, N.W.H., Mashimba, E.N.M., (1990) Carbohydr. Polym, 14, p. 17; Shelanski, S.H., Clark, A.M., (1948) Food Res, 13, p. 29; Kern, W., (1959) Pharm. Ind, 21, p. 45; Domsche, A., (1992) Die kosmetischen Präparate, , Verlag für die Chemische Industrie, Augsburg; Pomeranz, Y., (1991) Functional Properties of Food Components, , 2nd edition, Academic Press, San Diego; Belitz, H.-D., Grosch, W., (1992) Lehrbuch der Lebensmittelchemie, , 4th edition, Springer, Berlin; Adden, R., Melander, C., Brinkmalm, G., Gorton, L., Mischnick, P., (2006) Biomacromolecules, 7, p. 1399; Pavlov, G., Michaeilova, N., Tarabukina, E., Korneeva, E., (1995) Prog. Colloid Polym. Sci, 99, p. 109; Yamakawa, H., Fujii, M., (1973) Macromolecules, 6, p. 407; Bushin, S., Tsvetkov, V., Lysenko, E., Emelianov, V., (1981) Vysokomol Soedin, 23 A, p. 2494; Bohdanecky, M., (1983) Macromolecules, 16, p. 1483; Pavlov, G.M., Rowe, A.J., Harding, S.E., (1997) Trends Anal. Chem, 16, p. 401; Ortega, A., Metodologías computacionales para propiedades en disolución de macromoléculas rígidas y flexibles (2005), Ph.D. Dissertation, Universidad de Murcia, SpainOrtega, A., García de la Torre, J., (2007) Biomacromolecules, 8, p. 2464; Adden, R., Müller, R., Mischnick, P., (2006) Macromol. Chem. Phys, 207, p. 954; Adden, R., Melander, C., Brinkmalm, G., Gorton, L., Mischnick, P., (2006) Biomacromolecules, 7, p. 1399; Melander, C., Adden, R., Brinkmalm, G., Gorton, L., Mischnick, P., (2006) Biomacromolecules, 7, p. 1410; Doty, P., Schneider, N.S., Holtzer, A.J., (1953) Am. Chem. Soc, 75, p. 754; Neely, W.B., (1963) J. Polym. Sci. A, 1, p. 531; Schuck, P., (1998) Biophys. J, 75, p. 1503; Schuck, P., Rossmanith, P.P., (2000) Biopolymers, 54, p. 328; Huggins, M.L., (1942) J. Am. Chem. Soc, 64, p. 2716; Harding, S.E., (1997) Prog. Biophys. Mol. Biol, 68, p. 207; Jumel, K., Harding, S.E., Mitchell, J.R., To, K.M., Hayter, I., O'Mullane, J.E., Ward-Smith, S., (1996) Carbohyd. Polym, 29, p. 105; Cilurzo, F., Selmin, F., Minghetti, P., Montanari, L., Lenardi, C., Orsini, F., Poletti, G., (2005) AAPS PharmSciTech, 6, pp. E586; Tanford, C., (1961) Physical Chemistry of Macromolecules, , John Wiley and Sons, New York; Wales, M., van Holde, K.E., (1954) J. Polym. Sci, 14, p. 81; Morris, G.A., Foster, T.J., Harding, S.E., (2000) Food Hydrocolloid, 14, p. 227; Morris, G.A., García de la Torre, J., Ortega, A., Castile, J., Smith, A., Harding, S.E., (2008) Food Hydrocolloids, 22, p. 1435; Picout, D.R., Ross-Murphy, S.B., Errington, N., Harding, S.E., (2001) Biomacromolecules, 2, p. 1301; Kratky, O., Porod, G., (1949) Recl. Trav. Chim. Pays-Bas, 68, p. 1106; Tombs, M., Harding, S.E., (1998) An Introduction to Polysaccharide Biotechnology, , Taylor and Francis, London; Stockmayer, W.H., Fixman, M.J., (1963) J. Polym. Sci. C, 1, p. 137; Hearst, J.E., (1963) J. Chem. Phys, 38, p. 1062; Hearst, J.E., Stockmayer, W.H., (1962) J. Chem. Phys, 37, p. 1425; Bueche, F., (1952) J. Chem. Phys, 20, p. 1959
Depositing User: Gordon Morris
Date Deposited: 20 May 2011 09:32
Last Modified: 06 Apr 2018 16:56


Downloads per month over past year

Repository Staff Only: item control page

View Item View Item

University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©