Buselli, E., Smith, Alan M., Grover, Liam M., Levi, A., Allman, R., Mattoli, V., Menciassi, A. and Beccai, L. (2011) Development and characterization of a bio-hybrid skin-like stretchable electrode. Microelectronic Engineering , 88 (8). pp. 1676-1680. ISSN 0167-9317
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This work presents the design, fabrication and characterization of a polymer based stretchable electrode for cell monitoring. The final goal is the development of innovative bio-hybrid skin-like tactile sensors with mammalian cells as core biological elements; to achieve such aim the enabling technological approach is pursued in this investigation. Electrodes are needed to detect cells response, thus the first step of the bio-hybrid system fabrication is the development of a platform able to record such response and transmit it to the external world. The stretchable electrode is composed by a conductive layer (few Ǻ of Ti plus 90 nm of Au) on a polymeric substrate (1 mm thick PDMS membrane). Cellular adhesion was verified and cellular response to an induced electrode strain of 1% was detected through fluorescence microscopy. Fluorescence intensities were 104.82 ± 9.64 a.u. and 129.66 ± 13.06 a.u. prior and during electrode strain, respectively. Electromechanical characterization of the stretchable electrode revealed excellent stability and reliability within the 1% strain, which is the operative range identified for the future tactile sensor application. Results showed that the electrode was conductive up to 14% of strain. Furthermore, frequency impedance measurements demonstrated the electrode capability of detecting presence of cells.
|Subjects:||Q Science > Q Science (General)|
R Medicine > RL Dermatology
R Medicine > RS Pharmacy and materia medica
T Technology > TA Engineering (General). Civil engineering (General)
T Technology > TK Electrical engineering. Electronics Nuclear engineering
|Schools:||School of Applied Sciences|
|Depositing User:||Alan Smith|
|Date Deposited:||24 Mar 2011 12:53|
|Last Modified:||17 Jan 2012 10:21|
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