Smith, Alan M., Ingham, Andrew, Grover, Liam M. and Perrie, Yvonne (2010) Polymer film formulations for the preparation of enteric pharmaceutical capsules. Journal of Pharmacy and Pharmacology, 62 (2). pp. 167-172. ISSN 0022-3573
- Published Version
Restricted to Repository staff only
Standard pharmaceutical capsules are designed to dissolve in the acidic environment of the stomach releasing the encapsulated contents for absorption. When release is required further along the gastrointestinal tract capsules can be coated with acid insoluble polymers to enable passage through the stomach and dissolution in the intestine. This paper describes formulations that have the potential to be used to produce two-piece hard capsules for post-gastric delivery without the requirement of an exterior coat.
The formulation uses three polysaccharides: sodium alginate, hypromellose and gellan gum to provide acid insolubility and the ability to form a capsule using standard industrial equipment.
The rheological profile on cooling, of the base material, water content and thickness of the films were shown to be comparable with those of commercial capsules. The capsules remained intact for 2 h in 100 mM HCl at pH 1.2 and within 5 min of being removed from the acid and submerged in phosphate-buffered saline at pH 6.8 were
Selected formulations from this study have potential for use as delayed release capsules.
|Subjects:||Q Science > Q Science (General)
Q Science > QD Chemistry
R Medicine > RS Pharmacy and materia medica
|Schools:||School of Applied Sciences|
|Depositing User:||Alan Smith|
|Date Deposited:||21 Mar 2011 16:40|
|Last Modified:||11 Nov 2015 05:32|
Downloads per month over past year
Repository Staff Only: item control page