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Polymer film formulations for the preparation of enteric pharmaceutical capsules

Smith, Alan M., Ingham, Andrew, Grover, Liam M. and Perrie, Yvonne (2010) Polymer film formulations for the preparation of enteric pharmaceutical capsules. Journal of Pharmacy and Pharmacology, 62 (2). pp. 167-172. ISSN 0022-3573

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    Abstract

    Objectives
    Standard pharmaceutical capsules are designed to dissolve in the acidic environment of the stomach releasing the encapsulated contents for absorption. When release is required further along the gastrointestinal tract capsules can be coated with acid insoluble polymers to enable passage through the stomach and dissolution in the intestine. This paper describes formulations that have the potential to be used to produce two-piece hard capsules for post-gastric delivery without the requirement of an exterior coat.
    Methods
    The formulation uses three polysaccharides: sodium alginate, hypromellose and gellan gum to provide acid insolubility and the ability to form a capsule using standard industrial equipment.
    Key findings
    The rheological profile on cooling, of the base material, water content and thickness of the films were shown to be comparable with those of commercial capsules. The capsules remained intact for 2 h in 100 mM HCl at pH 1.2 and within 5 min of being removed from the acid and submerged in phosphate-buffered saline at pH 6.8 were
    ruptured.
    Conclusions
    Selected formulations from this study have potential for use as delayed release capsules.

    Item Type: Article
    Subjects: Q Science > Q Science (General)
    Q Science > QD Chemistry
    R Medicine > RS Pharmacy and materia medica
    Schools: School of Applied Sciences
    Depositing User: Alan Smith
    Date Deposited: 21 Mar 2011 16:40
    Last Modified: 21 Mar 2011 16:40
    URI: http://eprints.hud.ac.uk/id/eprint/9878

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