Search:
Computing and Library Services - delivering an inspiring information environment

Relative bioavailability of terbutaline to the lung following inhalation, using urinary excretion

Abdelrahim, Mohamed E., Assi, Khaled H. and Chrystyn, Henry (2011) Relative bioavailability of terbutaline to the lung following inhalation, using urinary excretion. British Journal of Clinical Pharmacology, 71 (4). pp. 608-610. ISSN 1365-2125

Metadata only available from this repository.

Abstract

The urinary salbutamol pharmacokinetic to determine relative lung and systemic bioavailability has been extended to terbutaline.

Mean(SD) urinary terbutaline 0.5h post inhalation, in 12 volunteers, with (IC) and without (I) oral charcoal and oral (O) dosing was 7.4(2.2), 6.5(2.1) and 0.2(0.2)µg. I and IC were similar and both significantly greater than O (p < 0.001). Urinary 24h terbutaline post I was similar to IC + O. The method was linear and reproducible similar to that of the urinary salbutamol method.

The urinary salbutamol pharmacokinetic method post inhalation applies to terbutaline. Terbutaline study doses can replace routine salbutamol during these studies when patients are studied.

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH301 Biology
Schools: School of Applied Sciences
Related URLs:
Depositing User: Sara Taylor
Date Deposited: 17 Mar 2011 10:58
Last Modified: 17 Mar 2011 14:35
URI: http://eprints.hud.ac.uk/id/eprint/9855

Item control for Repository Staff only:

View Item

University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©