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Effects of the aqueous extract of Bridelia ferruginea stem bark on carrageenan-induced oedema and granuloma tissue formation in rats and mice.

Olajide, Olumayokun A, Makinde, J M and Awe, S O (1999) Effects of the aqueous extract of Bridelia ferruginea stem bark on carrageenan-induced oedema and granuloma tissue formation in rats and mice. Journal of ethnopharmacology, 66 (1). pp. 113-117. ISSN 0378-8741

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Abstract

The anti-inflammatory activity of the aqueous extract of the stem bark of Bridelia ferruginea was evaluated using carrageenan-induced paw oedema in rats and mice, and the cotton pellet granuloma method. The extract at doses ranging from 10 to 80 mg/kg p.o. significantly inhibited the carrageenan-induced rat paw oedema, with an ID50 value of 36 mg/kg. However, a low activity was produced in the mouse paw oedema. The extract also suppressed the granulomatous tissue formation of chronic inflammation. B. ferruginea therefore proved to be effective in both the acute and chronic phases of the inflammatory process.

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Schools: School of Applied Sciences
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Depositing User: Olumayokun Olajide
Date Deposited: 09 Nov 2010 16:18
Last Modified: 09 Nov 2010 16:18
URI: http://eprints.hud.ac.uk/id/eprint/8989

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