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Evaluation of the anti-diabetic property of Morinda lucida leaves in streptozotocin-diabetic rats.

Olajide, Olumayokun A, Awe, S O, Makinde, J M and Morebise, O (1999) Evaluation of the anti-diabetic property of Morinda lucida leaves in streptozotocin-diabetic rats. The Journal of pharmacy and pharmacology, 51 (11). pp. 1321-1324. ISSN 0022-3573

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Abstract

The hypoglycaemic and anti-hyperglycaemic activities of a methanol extract of Morinda lucida Benth. (Rubiaceae) leaves were studied in normal and streptozotocin-diabetic rats. In normal rats, the extract demonstrated a significant (P < 0.05) and dose-dependent hypoglycaemic activity within 4 h after oral administration. The plasma glucose level of 400 mg kg(-1) of the extract at 4 h was 42.5 +/- 0.4 mg/100 mL (control 67.4 +/- 1.2 mg/100 mL). After 12 h, the plasma glucose level of rats administered 50, 100, 200 or 400 mg kg(-1) extract fell to 51.9 +/- 1.2, 47.3 +/- 0.8, 43.1 +/- 0.4 and 40.0 +/- 0.5 mg/100 mL, respectively. In hyperglycaemic rats, the extract produced a significant (P < 0.05) anti-diabetic effect from day 3 after oral administration, with 400 mg kg(-1) extract-treated animals having a plasma glucose level of 248.7 +/- 5.3 mg/100 mL compared with glibenclamide (10 mg kg(-1))-treated animals with a plasma glucose level of 251.5 +/- 5.8 mg/100 mL. These results suggest that the leaves of Morinda lucida have a strong glucose lowering property when administered to streptozotocin-treated rats.

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Schools: School of Applied Sciences
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Depositing User: Olumayokun Olajide
Date Deposited: 09 Nov 2010 16:23
Last Modified: 09 Nov 2010 16:23
URI: http://eprints.hud.ac.uk/id/eprint/8988

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