Search:
Computing and Library Services - delivering an inspiring information environment

Effects of Anacardium occidentale stem bark extract on in vivo inflammatory models.

Olajide, Olumayokun A, Aderogba, Mutallib A, Adedapo, Aduragbenro D A and Makinde, J M (2004) Effects of Anacardium occidentale stem bark extract on in vivo inflammatory models. Journal of ethnopharmacology, 95 (2-3). pp. 139-42. ISSN 0378-8741

Metadata only available from this repository.

Abstract

The methanol extract of Anacardium occidentale stem bark was evaluated for activities against the lipopolysaccharide (LPS)-induced septic shock, as well as LPS-induced microvascular permeability in mice. Pre-treatment with Anacardium occidentale extract (25-200 mg/kg) caused a dose-dependent and significant (p < 0.05) reduction in the elevated levels of alanine and aspartate aminotransferases in the sera of D-galactosamine-primed mice injected with LPS. The highest dose of the extract studied (200 mg/kg) produced a 100% protection against death from sepsis. Pentoxifylline (100 mg/kg) and L-NAME (5 mg/kg) offered 100% protection against LPS-induced septic shock, and produced marked reduction in elevated levels of transferases. A dose-related inhibition of LPS-induced microvascular permability in mice was also produced by pentoxifylline, L-NAME and the extract.

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Schools: School of Applied Sciences
Related URLs:
Depositing User: Olumayokun Olajide
Date Deposited: 10 Nov 2010 10:35
Last Modified: 10 Nov 2010 10:35
URI: http://eprints.hud.ac.uk/id/eprint/8979

Item control for Repository Staff only:

View Item

University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©