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Enhanced chlorhexidine skin penetration with eucalyptus oil

Karpanen, T.J., Conway, Barbara R, Worthington, T., Hilton, A.C., Elliott, T.S.J. and Lambert, P.A. (2010) Enhanced chlorhexidine skin penetration with eucalyptus oil. BMC Infectious Diseases, 10 (278). pp. 1-6. ISSN 1471-2334

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Abstract

Background
Chlorhexidine digluconate (CHG) is a widely used skin antiseptic, however it poorly penetrates the skin, limiting its efficacy against microorganisms residing beneath the surface layers of skin. The aim of the current study was to improve the delivery of chlorhexidine digluconate (CHG) when used as a skin antiseptic.

Method
Chlorhexidine was applied to the surface of donor skin and its penetration and retention under different conditions was evaluated. Skin penetration studies were performed on full-thickness donor human skin using a Franz diffusion cell system. Skin was exposed to 2% (w/v) CHG in various concentrations of eucalyptus oil (EO) and 70% (v/v) isopropyl alcohol (IPA). The concentration of CHG (μg/mg of skin) was determined to a skin depth of 1500 μm by high performance liquid chromatography (HPLC).

Results
The 2% (w/v) CHG penetration into the lower layers of skin was significantly enhanced in the presence of EO. Ten percent (v/v) EO in combination with 2% (w/v) CHG in 70% (v/v) IPA significantly increased the amount of CHG which penetrated into the skin within 2 min.

Conclusion
The delivery of CHG into the epidermis and dermis can be enhanced by combination with EO, which in turn may improve biocide contact with additional microorganisms present in the skin, thereby enhancing antisepsis.

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology
R Medicine > RC Internal medicine
Schools: School of Applied Sciences
Depositing User: Graham Stone
Date Deposited: 15 Oct 2010 14:38
Last Modified: 27 Sep 2011 08:38
URI: http://eprints.hud.ac.uk/id/eprint/8847

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