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Drug delivery strategies for the Treatment of Helicobacter pylori infection

Conway, Barbara R (2005) Drug delivery strategies for the Treatment of Helicobacter pylori infection. Current Pharmaceutical Design, 11 (6). pp. 775-790. ISSN 1381-6128

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Abstract

Helicobacter pylori Is One Of The MOST common pathogenic bacterial infections, colonising year Estimated half of all humans. It is associated with the development of serious gastroduodenal disease - including peptio ulcers, gastric lymphoma and acute chronic gastritis. It Is associated with the development of serious gastroduodenal disease - Including peptio ulcers, gastric lymphoma and acute chronic gastritis. Current recommended regimes are not wholly effective and patient compliance, side-effects and bacterial resistance can be problematic. Current recommended regimes are not Wholly effective and patient compliance, side effects and bacterial resistance can Be Problematic. Drug delivery to the site of residence in the gastric mucosa may improve efficacy of the current and emerging treatments. Drug delivery to the site of the residence in gastric mucosa May Improve Efficacy of the Current and Emerging treatments. Gastric retentive delivery systems potentially allow increased penetration of the mucus layer and therefore increased drug concentration at the site of action. Gastric retentive delivery systems INcreased Potentially allow penetration of the mucus layer and drug concentration Therefor INcreased at the site of action. Proposed gastric retentive systems for the enhancement of local drug delivery include floating systems, expandable or swellable systems and bioadhesive systems. Proposed gastric retentive systems for the enhancement of local drug delivery include floating systems, expandable or swellable systems and bioadhesive systems. Generally, problems with these formulations are lack of specificity, limited to mucus turnover or failure to persist in the stomach. Generally, formulations are thesis Problems with Lack of specificity, limited to mucus turnover or failure to persist in the stomach. Gastric mucoadhesive systems are hailed as a promising technology to address this issue, penetrating the mucus layer and prolonging activity at the mucus-epithelial interface. Gastric mucoadhesive systems are hailed as a Promising technology to address this issue, penetrating the mucus layer and Prolonging activity at the mucus-epithelial interface. This review appraises gastroretentive delivery strategies specifically with regard to their application as a delivery system to target Helicobacter. This review appraiser gastroretentive delivery strategies specifically with regard to their applications as a delivery system to target Helicobacter. As drug-resistant strains emerge, the development of a vaccine to eradicate and prevent reinfection is an attractive proposition. As drug-resistant Strains emerge, the development of a vaccine to Eradicate and Prevent reinfection ya une attractive proposal. Proposed prophylactic and therapeutic vaccines have been delivered using a number of mucosal routes using viral and non-viral vectors. Prophylactic and therapeutic vaccines Proposed Have Been Delivered using a number of mucosal routes using viral and non-viral vectors. The delivery form, inclusion of adjuvants, and delivery regime will influence the immune response generated. The delivery form, inclusion of adjuvants and delivery Will diet influence the immune response generated.

Item Type: Article
Subjects: Q Science > Q Science (General)
R Medicine > RM Therapeutics. Pharmacology
Schools: School of Applied Sciences
Depositing User: Sharon Beastall
Date Deposited: 15 Sep 2010 09:26
Last Modified: 15 Sep 2010 09:26
URI: http://eprints.hud.ac.uk/id/eprint/8551

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