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Comparative physical, mechanical and crystallographic properties of a series of gemfibrozil salts

David, Sarah E., Ramirez, Miren, Timmins, Peter and Conway, Barbara R (2010) Comparative physical, mechanical and crystallographic properties of a series of gemfibrozil salts. Journal of Pharmacy and Pharmacology, 62 (11). pp. 1519-1525. ISSN 2042-7158

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Abstract

Objectives  Understanding the impact of the counterion on the properties of an acidic or basic drug may influence the choice of salt form, especially for less potent drugs with a high drug load per unit dose. The aim of this work was to determine the influence of the hydrogen bonding potential of the counterion on the crystal structure of salts of the poorly soluble, poorly compressible, acidic drug gemfibrozil and to correlate these with mechanical properties.

Methods  Compacts of the parent drug and the salts were used to determine Young's modulus of elasticity using beam bending tests. Crystal structures were determined previously from X-ray powder diffraction data.

Key findings  The free acid, tert-butylamine, 2-amino-2-methylpropan-1-ol and 2-amino-2-methylpropan-1,3-diol salts had a common crystal packing motif of infinite hydrogen-bonded chains with cross-linking between pairs of adjacent chains. The tromethamine (trsi) salt, with different mechanical properties, had a two-dimensional sheet-like network of hydrogen bonds, with slip planes, forming a stiffer compact.

Conclusions  The type of counter ion is important in determining mechanical properties and could be selected to afford slip and plastic deformation

Item Type: Article
Subjects: Q Science > Q Science (General)
R Medicine > RM Therapeutics. Pharmacology
Schools: School of Applied Sciences
Related URLs:
Depositing User: Sharon Beastall
Date Deposited: 10 Sep 2010 11:51
Last Modified: 18 Jul 2012 12:08
URI: http://eprints.hud.ac.uk/id/eprint/8511

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