Search:
Computing and Library Services - delivering an inspiring information environment

Intramolecular 1,3-dipolar cycloaddition as a route to triazolobenzodiazepines and pyrrolobenzodiazepines

Hemming, Karl (2010) Intramolecular 1,3-dipolar cycloaddition as a route to triazolobenzodiazepines and pyrrolobenzodiazepines. Tetrahedron Letters, 51 (37). pp. 4859-4861. ISSN 0040-4039

[img] PDF - Published Version
Restricted to Repository staff only

Download (473kB)

    Abstract

    Intramolecular 1,3-dipolar cycloaddition between an alkyne and an azide leads to a series of 1,2,3-triazolo-fused 1,4-benzodiazepines, 1,2,5-benzothiadiazepines, pyrrolobenzodiazepines and pyrrolobenzothiadiazepines (8 examples). The products are privileged structures in medicinal chemistry. The precursor azido alkynes are obtained, usually as transient intermediates, by treatment of the corresponding aldehydes (derived from α-amino acids) with the Bestmann-Ohira reagent.

    Item Type: Article
    Subjects: Q Science > QD Chemistry
    Schools: School of Applied Sciences
    Related URLs:
    Depositing User: Karl Hemming
    Date Deposited: 25 Aug 2010 15:39
    Last Modified: 25 Aug 2010 15:39
    URI: http://eprints.hud.ac.uk/id/eprint/8382

    Document Downloads

    Downloader Countries

    More statistics for this item...

    Item control for Repository Staff only:

    View Item

    University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©