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Glucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma?

Cooper, R, Sarioğlu, S, Sökmen, S, Füzün, M, Küpelioğlu, A, Valentine, H, Görken, I B, Airley, Rachel and West, Catharine M.L. (2003) Glucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma? British Journal of Cancer, 89 (5). pp. 870-876. ISSN 0007-0920

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Abstract

The aim of the study is to evaluate the pattern and level of expression of glucose transporter-1 (GLUT-1) in rectal carcinoma in relation to outcome as a potential surrogate marker of tumour hypoxia. Formalin-fixed tumour sections from 43 patients with rectal carcinoma, who had undergone radical resection with curative intent, were immunohistochemically stained for GLUT-1. A mean of three sections per tumour (range 1–12) were examined. Each section was semiquantitatively scored; 0, no staining; 1, <10%; 2, 10–50%; 3, >50% and a score given for the whole section, the superficial (luminal) and deep (mural) part of the tumour. Staining was seen in 70% of tumours. Increased staining was noted adjacent to necrosis and ulceration. A diffuse and patchy pattern of staining, with and without colocalisation to necrosis was seen. Patients with high GLUT-1-expressing tumours (score 3 vs 0–2) had a significantly poorer overall survival (P=0.041), which was associated with poorer metastasis-free survival with no difference in local control. No significant correlation was seen with other prognostic factors. There was a strong correlation between the score for the superficial and deep parts of the tumour (r=0.81), but a significant relationship with outcome was only found in the deep part (P=0.003 vs P=0.46). In conclusion, increased GLUT-1 expression in rectal tumours was an adverse prognostic factor and is worth further evaluation as a predictive marker of response to therapy.

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QP Physiology
Schools: School of Applied Sciences
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Depositing User: Sharon Beastall
Date Deposited: 08 Jul 2010 09:23
Last Modified: 12 Jan 2011 11:36
URI: http://eprints.hud.ac.uk/id/eprint/8067

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