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Evaluation of supercritical fluid engineered budesonide powder for respiratory delivery using nebulisers

Amani, Amir, Chrystyn, Henry, Clark, Brian J., Abdelrahim, Mohamed. E and York, Peter (2009) Evaluation of supercritical fluid engineered budesonide powder for respiratory delivery using nebulisers. Journal of Pharmacy and Pharmacology, 61 (12). pp. 1625-1630. ISSN 0022-3573

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Abstract

Objectives:

Currently, suspensions prepared from micronised drug substances are the only delivery system marketed for nebulisation of steroids, and reported inconsistent or low bioavailability arising from their use provides a rationale for researching alternative formulations. Supercritical fluid processing of drug substances to obtain respirable-sized particles has been used over the last decade to formulate dry powder inhalers. We aimed thus to process budesonide powder to improve its deposition characteristics.

Methods:

In an attempt to overcome the limitations of nebuliser suspensions when prepared from micronised drug particles, budesonide powder was processed using a supercritical fluid based process and suspended using Tween 80 as a surfactant to provide an aqueous nebuliser formulation. The in-vitro characteristics of the emitted dose on nebulisation for the prepared suspension were then compared to a commercially available suspension formulation of budesonide using a jet and a vibrating mesh nebuliser.

Key findings:

The results showed a significant improvement of the in-vitro deposition properties of the suspension containing supercritical fluid engineered budesonide particles.

Conclusions:

The results indicated the benefit of such materials compared with traditionally micronised drug powders.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Schools: School of Applied Sciences
Related URLs:
Depositing User: Sharon Beastall
Date Deposited: 11 Mar 2010 12:58
Last Modified: 12 Mar 2010 08:51
URI: http://eprints.hud.ac.uk/id/eprint/7172

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