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Orbital steering, entropy, and rate accelerations

Jencks, William P. and Page, Michael I. (1974) Orbital steering, entropy, and rate accelerations. Biochemical and Biophysical Research Communications, 57 (3). pp. 887-892. ISSN 0006-291X

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Abstract

Some important conceptual and quantitative differences are described between the “orbital steering” and entropy descriptions of the rate accelerations in intramolecular and enzymic reactions that may be brought about by geometric constraints other than distortion. The treatments differ by a factor of 103 – 104 in the maximum rate acceleration that may be obtained from these constraints. The estimation of a “proximity factor” without taking adequate account of the translational and overall rotational entropy terms gives a misleading value for this factor. The conclusion is reaffirmed that increasing the probability of reaction by restricting the free translational and rotational movement of reacting groups can play a large role in the catalytic power of enzymes

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Schools: School of Applied Sciences
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Depositing User: Sharon Beastall
Date Deposited: 12 Nov 2009 12:36
Last Modified: 12 Nov 2009 12:36
URI: http://eprints.hud.ac.uk/id/eprint/6226

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