Search:
Computing and Library Services - delivering an inspiring information environment

The effect of increasing the hydrophobicity of penicillin on its micelle-catalysed hydrolysis

Gensmantel, Nigel P. and Page, Michael I. (1982) The effect of increasing the hydrophobicity of penicillin on its micelle-catalysed hydrolysis. Journal of the Chemical Society, Perkin Transactions 2 (2). pp. 155-159. ISSN 1472-779X

Metadata only available from this repository.

Abstract

Micelles of cetyltrimethylammonium bromide catalyse the alkaline hydrolysis of alkylpenicillins and benzylpenicillin methyl ester, The equilibrium constant for binding the alkylpenicillin to the micelle and the rate constants have been obtained. Binding increases with increasing alkyl chain length but shows a non-linear dependence upon the Hansch -value and the rate reaches a maximum value with heptylpenicillin. The free energy of transfer of a methylene group from water to the micelle shows a maximum value of 0.71 kcal mol–1. The negative charge of the carboxytate group of penicillin is not necessary tor catalysis

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Schools: School of Applied Sciences
Related URLs:
Depositing User: Sharon Beastall
Date Deposited: 11 Nov 2009 13:42
Last Modified: 11 Nov 2009 13:42
URI: http://eprints.hud.ac.uk/id/eprint/6181

Item control for Repository Staff only:

View Item

University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©