Morris, Jeffrey J. and Page, Michael I. (1978) Intramolecular nucleophilic and general acid catalysis in the hydrolysis of an amide. Chemical Communications (14). p. 591. ISSN 1359-7345Metadata only available from this repository.
The relative effectiveness of intramolecular nucleophilic and general acid catalysis are compared in the hydroxide-ion catalysed hydrolysis of N-(2-amino-ethyl)-2-endo-hydroxy-6-endo-norbornamide in its amino protonated form; the rate enhancement of ca. 109 is due mainly to nucleophilic catalysis by the neighbouring hydroxy group with only a relatively minor contribution from the protonated amino group acting as a general acid.
|Subjects:||Q Science > Q Science (General)
Q Science > QD Chemistry
|Schools:||School of Applied Sciences|
|Depositing User:||Sharon Beastall|
|Date Deposited:||11 Nov 2009 12:48|
|Last Modified:||11 Nov 2009 12:48|
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